Langsung ke konten utama

Pharmacokinetic and Pharmacodynamic Data Analysis: Concepts and Applications, Third Edition (9186274929)



This is a revised and very expanded version of the previous second edition of the book.

"Pharmacokinetic and Pharmacodynamic Data Analysis" provides an introduction into pharmacokinetic and pharmacodynamic concepts using simple illustrations and reasoning. It describes ways in which pharmacodynamic and pharmacodynamic theory may be used to give insight into modeling questions and how these questions can in turn lead to new knowledge. This book differentiates itself from other texts in this area in that it bridges the gap between relevant theory and the actual application of the theory to real life situations.

The book is divided into two parts; the first introduces fundamental principles of PK and PD concepts, and principles of mathematical modeling, while the second provides case studies obtained from drug industry and academia. Topics included in the first part include a discussion of the statistical principles of model fitting, including how to assess the adequacy of the fit of a model, as well as strategies for selection of time points to be included in the design of a study. The first part also introduces basic pharmacokinetic and pharmacodynamic concepts, including an excellent discussion of effect compartment (link) models as well as indirect response models.

The second part of the text includes over 70 modeling case studies. These include a discussion of the selection of the model, derivation of initial parameter estimates and interpretation of the corresponding output. Finally, the authors discuss a number of pharmacodynamic modeling situations including receptor binding models, synergy, and tolerance models (feedback and precursor models).

This book will be of interest to researchers, to graduate students and advanced undergraduate students in the PK/PD area who wish to learn how to analyze biological data and build models and to become familiar with new areas of application. In addition, the text will be of interest to toxicologists interested in learning about determinants of exposure and performing toxicokinetic modeling.

The inclusion of the numerous exercises and models makes it an excellent primary or adjutant text for traditional PK courses taught in pharmacy and medical schools. A diskette is included with the text that includes all of the exercises and solutions using WinNonlin.


Product details

  • Hardback | 924 pages
  • 177.8 x 241.3 x 63.5mm | 1,860g
  • London, United Kingdom
  • English
  • New edition
  • 3rd New edition
  • 9186274929
  • 9789186274924


Download Pharmacokinetic and Pharmacodynamic Data Analysis: Concepts and Applications, Third Edition (9186274929).pdf, available at ebookdownloadfree.co for free.

>DOWNLOAD NOW<

Komentar

Posting Komentar

Postingan populer dari blog ini

Neurology : A Clinician's Approach (9783319296302)

This concise, thoroughly updated text provides a comprehensive, state-of-the art review of neurology and will serve as a highly practical resource for neurology residents and medical students. Emphasizing a practical approach to common neurologic disorders, the author blends chapters that cover the evaluation of specific complaints (confusion, dizziness and vertigo, visual loss, headache and facial pain) with others that focus on particular disorders (Parkinsonism, multiple sclerosis, dementia). Noting the core practice of neurology is largely unchanged from years ago and still largely done at the bedside, the author emphasizes the importance of acquiring expertise in the time-tested, classical techniques of history taking, directed examination, and localization. Toward that, the author encourages a focus on the key clinical pathways for diagnosis and management. A wide range of clinical pearls are provided and the diagrams and illustrations are well-designed and comprehensible, as are...
Posting Komentar
Baca selengkapnya

The Byzantine Dark Ages (9781472536037)

The Byzantine Dark Ages explores current debates about the sudden transformation of the Byzantine Empire in the wake of environmental, social and political changes. Those studying the Byzantine Empire, the successor to the Roman Empire in the eastern Mediterranean, have long recognized that the mid-7th century CE ushered in sweeping variations in the way of life of many inhabitants of the Mediterranean world, with evidence of the decline of the size and economic prosperity of cities, a sharp fall in expressions of literary culture, the collapse in trade networks, and economic and political instability. Michael J. Decker looks at the material evidence for the 7th to 9th centuries, lays out the current academic discourse about its interpretation, and suggests new ways of thinking about this crucial era. Important to readers interested in understanding how and why complex societies and imperial systems undergo and adapt to stresses, this clearly written, accessible work will also challeng...
Posting Komentar
Baca selengkapnya

The Vesuvius Club : A Lucifer Box Novel (9780743483797)

An Extraordinary and Death-Defying Tour of Edwardian Low Life and High Society, accompanied by our host Lucifer Box Esq - artist, dandy, rake ... and lethal secret agent. Lucifer Box is the darling of the Edwardian belle monde - society's most fashionable portrait painter is a wit, a dandy, a rake, the guest all hostesses (and not a few hosts) must have. But few know that Lucifer Box is also His Majesty's most accomplished and daring secret agent. Beneath London's facade of Imperial grandeur and divine aesthetes seethes an underworld of crazed anarchists, murder, and despicable vice, and Box is at home in both. And so of course when Britain's most prominent scientists begin turning up dead, there is only one man his country can turn to. Lucifer Box ruthlessly deduces and seduces his way from his elegant townhouse at Number 9 Downing Street (all his father left him), to private stews of London and the seediest, most colourful back alleys of Italy, in search of the mig...
Posting Komentar
Baca selengkapnya