Langsung ke konten utama

Pharmacokinetic and Pharmacodynamic Data Analysis: Concepts and Applications, Third Edition (9186274929)



This is a revised and very expanded version of the previous second edition of the book.

"Pharmacokinetic and Pharmacodynamic Data Analysis" provides an introduction into pharmacokinetic and pharmacodynamic concepts using simple illustrations and reasoning. It describes ways in which pharmacodynamic and pharmacodynamic theory may be used to give insight into modeling questions and how these questions can in turn lead to new knowledge. This book differentiates itself from other texts in this area in that it bridges the gap between relevant theory and the actual application of the theory to real life situations.

The book is divided into two parts; the first introduces fundamental principles of PK and PD concepts, and principles of mathematical modeling, while the second provides case studies obtained from drug industry and academia. Topics included in the first part include a discussion of the statistical principles of model fitting, including how to assess the adequacy of the fit of a model, as well as strategies for selection of time points to be included in the design of a study. The first part also introduces basic pharmacokinetic and pharmacodynamic concepts, including an excellent discussion of effect compartment (link) models as well as indirect response models.

The second part of the text includes over 70 modeling case studies. These include a discussion of the selection of the model, derivation of initial parameter estimates and interpretation of the corresponding output. Finally, the authors discuss a number of pharmacodynamic modeling situations including receptor binding models, synergy, and tolerance models (feedback and precursor models).

This book will be of interest to researchers, to graduate students and advanced undergraduate students in the PK/PD area who wish to learn how to analyze biological data and build models and to become familiar with new areas of application. In addition, the text will be of interest to toxicologists interested in learning about determinants of exposure and performing toxicokinetic modeling.

The inclusion of the numerous exercises and models makes it an excellent primary or adjutant text for traditional PK courses taught in pharmacy and medical schools. A diskette is included with the text that includes all of the exercises and solutions using WinNonlin.


Product details

  • Hardback | 924 pages
  • 177.8 x 241.3 x 63.5mm | 1,860g
  • London, United Kingdom
  • English
  • New edition
  • 3rd New edition
  • 9186274929
  • 9789186274924


Download Pharmacokinetic and Pharmacodynamic Data Analysis: Concepts and Applications, Third Edition (9186274929).pdf, available at ebookdownloadfree.co for free.

>DOWNLOAD NOW<

Komentar

Posting Komentar

Postingan populer dari blog ini

The Puffin Book of Fantastic First Poems (9780141308982)

The Puffin Book of Fantastic First Poems edited by June Crebbin will absorb and delight girls and boys aged 5+. A great first poetry book; the poems span time, from Robert Louis Stevenson and Walter de la Mare right up to date with Roger McGough and Michael Rosen. Themes covered, such as mealtimes, playtime, animals, family and bedtime, really appeal to youngreaders. A truly lovely collection of all-time favourite poems. June Crebbin is an ex-primary teacher, now a full-time writer. She is in great demand for author visits and runs very successful writing workshops in schools. June has written a wide range of children's books and writes poetry for children and adults. She lives in Leicester. Product details For ages 3-5 ...
Posting Komentar
Baca selengkapnya

The Ten Commandments of Progressive Christianity (9781662000874)

Not long ago, I came across a list of ten principles set forth by proponents of progressive Christianity. They are, in effect, a new Ten Commandments. What's striking is that they are far less about God revealing his desires and far more about man expressing his own--less Moses, more Oprah.Yet each of these commandments is partially true. Indeed, that is what makes this list, and progressive Christianity as a whole, so challenging. Half-truths can sound quite appealing until you recognize their foundations and implications. In this guide, I diagnose and critique each of these tenets and offer a brief biblical and theological response.Liberal Christianity never really goes away. If the church is going to hold fast to "the faith that was once for all delivered to the saints" (Jude 3), we must, in every era, be able to distinguish true faith from the false. Product details ...
Posting Komentar
Baca selengkapnya

The Visions of Ransom Lake (9780983807483)

Youthful beauty, naive innocence, a romantic imagination thirsting for adventure-an apt description of Vaden Valmont, who would soon find the adventure and mystery she had always longed to experience-in the form of a man.A somber recluse, Ransom Lake descended from his solitary concealment in the mountains, wholly uninterested in people and their trivial affairs. And somehow, young Vaden managed to be ever in his way, either by accident or because of her own unique ability to stumble into a quandary.Yet the enigmatic Ransom Lake would involuntarily become Vaden's unwitting tutor. Through him, she would experience joy and passion the like even Vaden had never imagined. Yes, Vaden Valmont stepped innocently, yet irrevocably, into love with the secretive, seemingly calloused manRansom Lake.But there were other life lessons Ransom Lake would inadvertently teach her as well-the darker side of life-despair, guilt, heartache. Would Ransom Lake be the means of Vaden's dreams come true...
Posting Komentar
Baca selengkapnya