Langsung ke konten utama

Pharmacokinetic and Pharmacodynamic Data Analysis: Concepts and Applications, Third Edition (9186274929)



This is a revised and very expanded version of the previous second edition of the book.

"Pharmacokinetic and Pharmacodynamic Data Analysis" provides an introduction into pharmacokinetic and pharmacodynamic concepts using simple illustrations and reasoning. It describes ways in which pharmacodynamic and pharmacodynamic theory may be used to give insight into modeling questions and how these questions can in turn lead to new knowledge. This book differentiates itself from other texts in this area in that it bridges the gap between relevant theory and the actual application of the theory to real life situations.

The book is divided into two parts; the first introduces fundamental principles of PK and PD concepts, and principles of mathematical modeling, while the second provides case studies obtained from drug industry and academia. Topics included in the first part include a discussion of the statistical principles of model fitting, including how to assess the adequacy of the fit of a model, as well as strategies for selection of time points to be included in the design of a study. The first part also introduces basic pharmacokinetic and pharmacodynamic concepts, including an excellent discussion of effect compartment (link) models as well as indirect response models.

The second part of the text includes over 70 modeling case studies. These include a discussion of the selection of the model, derivation of initial parameter estimates and interpretation of the corresponding output. Finally, the authors discuss a number of pharmacodynamic modeling situations including receptor binding models, synergy, and tolerance models (feedback and precursor models).

This book will be of interest to researchers, to graduate students and advanced undergraduate students in the PK/PD area who wish to learn how to analyze biological data and build models and to become familiar with new areas of application. In addition, the text will be of interest to toxicologists interested in learning about determinants of exposure and performing toxicokinetic modeling.

The inclusion of the numerous exercises and models makes it an excellent primary or adjutant text for traditional PK courses taught in pharmacy and medical schools. A diskette is included with the text that includes all of the exercises and solutions using WinNonlin.


Product details

  • Hardback | 924 pages
  • 177.8 x 241.3 x 63.5mm | 1,860g
  • London, United Kingdom
  • English
  • New edition
  • 3rd New edition
  • 9186274929
  • 9789186274924


Download Pharmacokinetic and Pharmacodynamic Data Analysis: Concepts and Applications, Third Edition (9186274929).pdf, available at ebookdownloadfree.co for free.

>DOWNLOAD NOW<

Komentar

Posting Komentar

Postingan populer dari blog ini

Captain Marvel Vol. 2: Civil War Ii (0785196439)

Old friends face off as bitter enemies in an event that will change Captain Marvel's life forever! As a new Civil War erupts, Carol Danvers finds herself at the very forefront of the conflict. But when tragedy hits too close to home, how far will she go to fight for what she believes in? As the rift with Iron Man grows ever deeper, Carol and the Alpha Flight recruit more to their cause: changing the future to protect the present. As wins mount up on Carol's side, she knows her mission is the right one - the only trouble is, not everyone agrees. Carol Danvers truly is one of Earth's Mightiest Heroes, and this is the story that proves it. It's Captain Marvel at her finest, in the fight of her life! COLLECTING: CAPTAIN MARVEL 6-10 Product details Format Paperback ...
Posting Komentar
Baca selengkapnya

The Beatles for Fingerstyle Ukulele (9781480368668)

(Ukulele). The Beatles for Fingerstyle Ukulele contains 25 favorite songs, each presented two ways: first as solo fingerstyle arrangements for playing simple chord-melody instrumentals with tab and chord diagrams included and also as lyric-and-chord lead sheets for basic strumming and singing. Songs are introduced in order of difficulty and also include fun and interesting facts about the Beatles' original recordings and history. Songs include: Across the Universe * And I Love Her * Can't Buy Me Love * Eight Days a Week * Here Comes the Sun * Hey Jude * In My Life * Lucy in the Sky with Diamonds * Something * While My Guitar Gently Weeps * Yesterday * You've Got to Hide Your Love Away * and more. Product details Format Book | 133 pages ...
Posting Komentar
Baca selengkapnya

The New Organic Grower, 3rd Edition : A Master's Manual of Tools and Techniques for the Home and Market Gardener, 30th Anniversary Edition (9781603588171)

Updated for its 30th anniversary edition; [This book] remains as relevant as ever. New York Times For anyone with an interest in sustainable growing, this is a must-read. Irish Times A perennial classic The New Organic Grower isone of the most important farming books available, written byEliot Coleman, a pioneer in the organic farming movement. Now fully illustrated and updated, this 30th Anniversary Edition is a must-have for any farmer or grower. Coleman's books and innovative methods have helped innumerable organic growers build successful farms in deep accordance with nature. The wisdom in this seminal book holds true even as the modern agricultural canon has grown - in large part due to Coleman's influence as a wise elder with decades of experience. New information has been included in this edition to showcase the new tools and techniques that Colemant has been developing over the last thirty-five years. The New Organic Grower offers a very approachable and productive for...
Posting Komentar
Baca selengkapnya